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But the science on this peptide is lacking (to put it lightly), so we dont know for sure

In the absence of insulin, IGF-I is necessary for human pluripotent stem cell maintenance (Wang et al.)

Salehi Z, Mashayekhi F, Naji M (2008) Insulin like growth factor-1 and insulin like growth factor binding proteins in the cerebrospinal fluid and serum from patients with Alzheimers disease

Rajguru and his team recognize that there are many benefits to combining them into one treatment

This selectivity is not just a laboratory distinction: in practice, it means patients can use Ipamorelin in twice-daily or three-times-daily protocols without the hormonal side effects that would limit longer-term use of the older compounds

Sermorelin is often prescribed off-label for adults for age-related GH decline or wellness benefits. Patients should understand that the FDA hasn't formally reviewed evidence for these specific unapproved uses, and insurance coverage may be limited. Adults considering sermorelin vs HGH for anti-aging should be aware that off-label protocols, while widely used, are not universally reimbursed and often require out-of-pocket payment