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However, as discussed below, the single screening round of DMSA had an unexpectedly dramatic effect on improving abnormal glutathione and platelet levels, and that effect lasted until the end of phase 2, so that phase 2 was not a placebo-controlled investigation

Nuclear factor E2-related factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming

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10.1016/j.bbi.2012.08.012 44 FrankelE

For example, ADC combining antibody and cytotoxic drugs could be a promising strategy to specifically target senescent cells with non-specific compounds