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Anti-tumor angiogenesis increases the normalization of blood vessels, inhibits tumor hypoxia and the immunosuppressive TME, increases the effective drug concentrations in tumors, and enhances drug efficacy

RIG-I (DDX58) interacts with MDA-5 and utilizes the mitochondrial adapter protein Cardif (IPS-1) to upregulate the expression of BH3-only proteins Puma and Noxa, thereby promoting intrinsic apoptosis in melanoma cells [162]

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The use of a culture-independent approach to derive polynucleotides encoding novel bioactivities from environmental samples is most preferable since it allows one to access untapped resources of biodiversity