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NLRP3, the most widely studied inflammasome, is a high molecular mass protein complex composed of NLRP3 protein, Apoptosis-associated Speck-like protein Containing a CARD (ASC), and cysteine aspartate protease 1 (caspase-1)

Clin Infect Dis 51(12):14291434 de Luca A, Smeekens SP, Casagrande A, Iannitti R, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LAB, van der Meer JWM, Chamilos G, Netea MG, Xavier RJ, Dinarello CA, Romani L, van de Veerdonk FL (2014) IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

Chronic inflammation Inflammation is a fundamental mechanism that maintains homeostasis in response to tissue damage (Racanelli et al., 2018

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Hematoxylin and eosin staining were performed for 5 min each on the sections