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Lastly, we tested whether cells that were functionally deficient in mitochondrial ETC metabolism, owing to mutations in CI and CIV, were differentially sensitive to 5FU treatment

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Many teenagers with polycystic ovary syndrome have insulin resistance and high insulin levels [39]

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214,215,216,217 Additionally, sensory neurons in the dorsal root ganglia (DRG) exhibit altered phenotypes, such as reduced neurofilament synthesis, endoplasmic reticulum stress, and changes in key plasticity molecules, such as growth-associated protein 43 (GAP43) and heat shock proteins, leading to mitochondrial dysfunction and loss of peripheral nerve function