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Katzke, Verena

ROS production The majority of ROS originate from the mitochondrial electron transport chain (METC)

Adhering to them isn't about being overly cautious

In addition, structural modifications, generating analogs, and conjugation for half-life extension, may be important for therapeutic development of MOTS-c [23]

[13] In the setting of acute isoniazid overdose or toxicity, extraordinarily high doses of pyridoxine are used as an antidote: the recommended approach is to administer pyridoxine in a total amount equal to the amount of isoniazid ingested

Conversely, elevated -syn inhibits intracellular trafficking and lysosomal function of normal GCase in neurons, indicating the presence of a bidirectional pathologic loop between GCase and -syn in PD and other synucleinopathies (Aflaki et al