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This study shows that a new pathophysiological model is scientifically mature, as basis for a new type of treatment of depression and, probably, of other psychiatric disorders, which replaces the old reductionist model and the standard therapy, even of a combined type (pharmacotherapy and psychotherapy together), which is of little efficacy

In other tissues, including the liver, skeletal muscle and macrophages, genetic disruption of clock genes has also been linked to changes in CI, CII and CIII respiration 6,37,38,39,40,41,42,43 , highlighting that clock regulation of mitochondrial function is shaped by cell type and metabolic state

Notably, this bidirectional effect of mitochondrial dysfunction in osteoclasts can be linked to specific clinical biomarkers of mitochondrial stress, which may predict the switch between pro-osteoclastogenic and anti-osteoclastogenic states

ROS can modify key proteins involved in sperm motility, such as actin and tubulin, through the formation of carbonyl groups

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