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Distinct variabilities of infection rates, epidemiological transmission, and clinical outcomes during COVID-19 pandemic raises an intriguing question, whether the emergence of SARS-CoV-2 variants of concern (VOCs) with function-specific mutations in ACE2, furin, and TMPRSS2 expression has played any role in disease manifestations and case fatality rates (CFR) 55,75

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These include hyperprolactinemia, thyroid disease, non-classical congenital adrenal hyperplasia (221, 222)

doi: 10.1021/cr500470n 148 LuC

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Wild-type zebrafish embryos serve as a robust system for investigating manganism 314 , while zebrafish carrying mutations in the slc30a10 , slc39a8 , and slc39a14 genes recapitulate many of the clinical phenotypes observed in humans 36,46,52