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It is also relevant that in recent studies, we have shown that TMAO directly interacts with human platelets (both isolated and in whole blood), altering stimulus-dependent calcium signaling and promoting platelet hyperresponsiveness (4)

Compounds such as allicin, diallyl disulfide (DADS), diallyl trisulfide (DATS), and ajoene exert broad-spectrum antimicrobial activity by oxidizing lowlow-molecular-weight thiols (e.g., glutathione) and disrupting protein thiol networks essential for DNA synthesis, respiration, and quorum sensing (Nakamoto et al., 2020)

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Free Radic Biol Med 83, 245251.CrossRefGoogle ScholarPubMed -glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study