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10.1016/j.biomaterials.2017.03.039 119 LeenaarsC

ALS pathogenic mutations identified in RNA-binding proteins (RBPs) include TAR DNA binding protein 43 (TDP-43), fused-in-sarcoma (FUS), Ewing sarcoma (EWS), TATA-binding protein-associated factor 15 (TAF15), and heterogeneous nuclear ribonucleoproteins (hnRNPs) 5,6

M., Delaidelli, A., Minaker, S

instead, they represent a collapse in proteostasis resilience, the intrinsic ability of cells to sense stress, mobilize coordinated responses and restore equilibrium across multiple proteostatic axes