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Moreover, direct elaboration of properly oriented substituent groups through various orthogonal chemistries provides further opportunities for the design of more complex JNK inhibitors: these composite molecules distinguish even between some of the JNK isoforms, which remained elusive so far with conventional warheads

These are reference figures, not approved human dosing

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The intuitive reason that GSH(t) is fairly stable is that GSH changes quite slowly when estradiol and S ( t ) vary

10.1074/jbc.M113.451849 309 SiesH.BerndtC.JonesD

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