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These checkpoints are expressed on T cells and induce T cell anergy, leading to an inhibition of T cell expansion and function [24]

Abdelzaher, W

Disruption of circadian rhythms disturbs the balance between pro- and anti-inflammatory cytokines, partly through altered immune cell trafficking and dysregulated clock proteins such as REV-ERB/NR1D1 (93).Innate immune cells such as macrophages and NK cells contain functional circadian clocks, with the CLOCK:BMAL1 heterodimer regulating phagocytosis, cytokine production (e.g., IL-1, TNF-), and antimicrobial activity (94)

Funding This research was funded by Fujian Medical University Union Hospital Talent Launch Fund Project (2024XH003) and Fujian Medical University Startup Fund for Scientific Research (2020QH2025)

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