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Description

Inhibition of Glutamate cysteine ligase depletes neuronal glutathione, elevates glutamate and increases excitatory neurotransmission Glutamate cysteine ligase (GCL) is the rate limiting step for glutathione synthesis, and utilizes glutamate as a substrate

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A future need for this AOP is a vigorous and thorough experiment model system to evaluate dose-response relationships, conentration-response relationships and exposure-effect relationships within the framework of this AOP

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