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304,307,308 Recent advancements include PLL nanoparticles coated with hyaluronic acid shells, significantly reducing cytotoxicity, enhancing cellular uptake, and improving gene expression

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Targeting the ATF4-dependent autophagy pathway could offer a therapeutic approach for patients with Fms-like tyrosine kinase 3 (FLT3) mutations, as Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) expression increases basal autophagy, which is essential for AML cell survival (40)

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Fortunately, we now have PDT, which is a much more modern approach to correcting Actinic Keratoses