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108 The gut is connected to the brain through the enteric nervous system (ENS), which includes parasympathetic nerves (vagus), sympathetic nerves (prevertebral ganglia), and the hypothalamic-pituitary-adrenal axis that flow out in parallel

Hardwick Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

Additionally, on-target/off-tumor gastrointestinal toxicity remains problematic

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