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Dysfunction of the PINK1-Parkin pathway in PD can lead to mitochondrial issues by obstructing mitophagy and disrupting ATP metabolism

Dilution means changing concentration after a solution already exists, usually by adding more solvent

doi: 10.1167/iovs.18-24813 14 NakamuraYKMeteaCKarstensLAsquithMGrunerHMoscibrockiCet al

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Using mRNA, anti-tumor responses occurred only after several infusions and during a time frame when the transferred cells most likely had lost their designed antigen-specificity due to the transient HBV-TCR expression after mRNA electroporation, while still other immunological alterations were detected [13,54]

Additionally, we observed increased expression of dysfunction and exhaustion-related signature genes while memory and effector-related gene expression was decreased in cystine-deprived T cells (Fig