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244 Upon pressure overload, lysosomal deoxyribonuclease (DNase) II deficiency in cardiomyocytes leads to mtDNA accumulation in autolysosomes, which subsequently activates TLR9 signaling-mediated inflammatory responses, contributing to heart failure

Brepocitinib, a JAK1 and TYK2 inhibitor, demonstrated clinically meaningful hair regrowth in patients with cicatricial alopecia, while ritlecitinib, a JAK3 and TEC kinase inhibitor, showed significant hair regrowth in patients with alopecia totalis or universalis

Nature 428:950-955, 2004

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