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Complete loss of GPX4 is incompatible with viability, and pharmacological or genetic GPX4 inhibition is widely exploited to induce ferroptosis in cells and tissues

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[DOI] [PubMed] [Google Scholar] 48.Hayakawa M., Miyashita H., Sakamoto I., Kitagawa M., Tanaka H., Yasuda H., Karin M., Kikugawa K

Upon amino acid/nutrient abundance, the mTORC1-dependent phosphorylation of Atg14-containing Vps34 complex inhibits the autophagosome biogenesis and suppresses autophagy