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(2019) systematically analyzed the metabolism of 271 orally administered drugs by 76 species/strains of human intestinal bacteria, identified bacterial genes and their products involved in drug metabolism, and validated some of the findings in mouse models and human gut microbiota cultures, deepening the understanding of the molecular mechanisms involved in drug metabolism by gut microbiota and providing insights into individualized drug interventions targeting microbiota

(1980) Does acrolein contribute to the cytotoxicity of cyclophosphamide

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Although the precise mechanism of IGFBP-2 oncogenesis in bladder cancer (or other cancers) is unclear, it has a defined role in stimulating angiogenesis and metastasis through IGF1R as described above [40], and its reported oncogenic signaling through integrin- 1 and ERK activation [46] is consistent with the known interaction between activated IGF1R and integrin- 1 with scaffolding by RACK1 and FAK, which promotes proliferative ERK signaling as well as EMT and increased invasiveness [47] (Fig

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