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Gene set enrichment analysis highlighted the early activation of oxidative stress-related pathways, including oxidative phosphorylation and ROS generation, as early as 1-h post-APAP exposure

This effect is closely associated with significant upregulation of iron metabolism-related genes (FPN), redox regulatory genes (GPX4, AIFM2), and key transcription factors (Nrf2, ATF4), offering new insights into stem cell derivative-based therapies for ferroptosis-related cardiac diseases [141]

This different localization seems to be evolutionarily retained due to the urge of a wise cellular exploitation of -ketoglutarate that in many organisms acts as a signal and coordinates carbon and nitrogen metabolism [19]

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10.1155/2019/6392763 65 HuangY.HuC.YeH.LuoR.FuX.LiX.et al (2019)