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Given its importance in the immune system, the NLRP3 inflammasome has drawn significant attention in the study of UC

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Published Research BPC-157 Tissue Signaling Seiwerth et al

The upregulation of IL-1 and TNF- respectively by colchicine and MCC950, however, was a bit surprising, and could possibly be explained by the interplay between these two cytokines in self-regulating each other, although further studies must be conducted to clarify this issue

Namely, moderate-dose exposure to noxious agents or factors induces an adaptive response of cells termed as hormesis

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