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Senescent cells promote inflammation and fibrosis by activating the p16/p21-Rb pathway and secreting senescence-associated secretory phenotype (SASP) factors, including IL-1, IL-6, IL-8, TGF-, plasminogen activator inhibitor (PAI), and insulin-like growth factor-1(IGF-1) (Lin et al., 2022

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Other strategies could also be effective in protein degradation like a nucleic acid-based strategy by using G-rich oligonucleotides that target the HIF-1 protein rather than its mRNA

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