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Combined NNMT inhibition and lean-diet substitution improves adiposity and body-composition endpoints in DIO mice

Researchers should prepare only the amount needed for near-term use

Once absorbed, 5-Amino-1MQ blocks NNMT activity in adipocytes

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The peptide retains activity in human gastric juice for more than 24 hours, tolerates pH from 1 to 11, and resists multiple proteolytic enzymes, properties that derive from the high proline content (four of fifteen residues) and the absence of cleavage-prone motifs

5-Amino-1MQ is a small molecule studied for its impact on metabolism and body composition