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Enhanced mitochondrial function during fasting further supports oxidative stress reduction by lowering free radical production [29, 32]

Nature 491:364373 Schulte ML, Fu A, Zhao P et al (2018) Pharmacological blockade of ASCT2-dependent glutamine transport leads to anti-tumor efficacy in preclinical models

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Ipamorelin : 2nd-generation GHRP, highly selective for GHS-R1a, no significant impact on cortisol or prolactin the current darling of modern protocols GHRP-6 : first generation, potent but triggers marked hunger (ghrelin-like action on the arcuate nucleus) and slight prolactin/cortisol elevation Hexarelin : most potent on acute GH release, but rapid GHS-R1a desensitization after prolonged use and more pronounced cortisol elevation Key point: GHRPs add an amplifying signal that potentiates GHRH, but chronic monotherapy triggers receptor down-regulation