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It is readily soluble in both aqueous and fat medium due to which it also referred to as universal antioxidant. It is absorbed from the dietary intake and is stored as dihydro lipoic acid (DHLA) (Smith et al., 2004)

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Third, sex differences in the OL lineage and myelination have been well described in rodents, although less so in humans 195,196

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It also reduces oxidative stress and makes skin quality better

Nevertheless, future research should focus on examining temporal relationships between HPA axis function and immune-inflammatory or nitrosative stress pathways through biomarkers like TNF-, IL-10, TGF-, inducible NO synthase, NO production, protein nitrosylation, and bacterial translocation in ME/CFS patients to better understand their roles [79]