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13 Although the pain is usually related to muscle activity, it may be constant

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Bilirubin precipitation and gallstone formation Bilirubin precipitation and gallstone formation are related to the supersaturation and impaired solubilization of bilirubin in bile, which could cause the improvement of pigment gallstones

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Because of their high metabolic activity, the adrenal glands, which are required for the production of steroid hormones that regulate different physiological processes, are vulnerable to oxidative damage ( 4 Oxidative stresses Oxidative stress occurs when prooxidant molecules like ROS and reactive nitrogen species (RNS) get produced in excess when antioxidant systems are not working efficiently (40)