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2017), with the number of adducts being 300500-fold higher than that of nuclear DNA (Marullo et al

Txnip is known to regulate intracellular redox as a thioredoxin-binding protein 43

Interestingly, in our sibling cohort we also observe that children with the most severe form of konzo (stage 3), have on average the lowest GPx3 levels as well as the largest difference when compared to unaffected siblings

Widening of the hepatic sinusoids, hyperactivation of Kupffer cells with atrophy of the hepatic cords, widespread severe vascular congestion (Table 2 and Fig