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A systematic evaluation of peripheral cytokines (e.g., via multiplex Luminex assays) will be conducted in follow-up studies to map gut-derived immune signals to CNS pathology

Next, we swapped the TM or C-terminus from ORF3a homologs with that in SARS-CoV-2 ORF3a

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Moreover, treatment with 10 ng/mL of IGF-1 for 10 days was demonstrated to be sufficient to induce tenogenic differentiation of bone marrow MSCs in 3D in vitro culture with significant upregulation of tenocytic markers (SCX, collagen type III, and decorin) (Durgam et al., 2012)

The peptide's primary mitogenic actions involve stimulation of the MAPK/ERK pathway, which promotes cell cycle progression, and the PI3K/Akt pathway, which enhances cell survival and prevents apoptosis

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