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Reports have shown that 90% of curcumin degradation under alkaline and neutral conditions occurred within 1530 min, while in acidic incubations, degradation was substantially slower, with less than 20% of total curcumin degraded within 60 min (71, 92)

Tests of both mitophagic blockers (XRK3F2, S1g-2) and inducers (PS compounds, Hemin, CBD, LCL-461, devimistat) have shown positive effects in specifically targeting leukemic cells with minimal effects on healthy hematopoietic cells

Hence, assessing an individual adequate dietary intake needs to consider polyphenol's bioavailability, which is different for every molecule, and is a very hard parameter to estimate: in fact, it is deeply affected by intestinal absorption, which can range from 3% of chlorogenic acid up to 43% of caffeic acid [50-51]

Learn dosing protocols, timelines, and what to expect

Schultz W, Dayan P, Montague PR

Cayman Chemical scientists are experts in building the tools needed to study how oxidized lipids are involved in the ferroptotic process