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Abbreviations BPH: Benign prostatic hyperplasia LUTSs: Lower urinary tract symptoms OS: Oxidative stress DEGs: Differentially expressed genes MXRA5: Matrix-remodeling associated 5 CXCL13: C-X-C Motif Chemokine Ligand 13 BMP5: Bone morphogenetic protein 5 NELL2: Neural epidermal growth factor-like like 2 GPX3: Glutathione peroxidase 3 GSH: Glutathione ROS: Reactive oxygen species Cyto-C: Cytochrome c MMP: Mitochondrial membrane potential PCD: Programmed cell death MDA: Malondialdehyde H&E: Hematoxylin and eosin staining IHC: Immunohistochemical DMSO: Dimethyl sulfoxide T: Testosterone propionate RSL3: RAS-selective lethal 3 GPX4: Glutathione peroxidase 4 TRO: Troglitazone PPAR: Peroxisome proliferator-activated receptor Rapa: Rapamycin CQ: Chloroquine Nrf2: Nuclear factor erythroid 2-related factor 2 SOD2: Superoxide dismutase 2

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Class I FINs activate ferroptosis by depleting intracellular GSH by inhibiting system X c - [17, 95, 103, 104]

Park, J., Wood, M

All inflammation, all disease, and everyones complaints are from two things

Thyroid autoimmunity with overt or subclinical hypothyroidism has been described in individuals with GSD Ib [13, 65]