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Disruption of the IGF-2/IGF-1R circuit abolishes CD74-NRG1-mediated tumor-initiating ability (Murayama et al., 2016)

(f) evasion of the immune system and

These kinases regulate key processes such as cell cycle progression, proliferation, and differentiation of intestinal stem cells into various specialized epithelial cell types, including enterocytes and goblet cells, critical for maintaining the structural and functional integrity of the intestinal barrier (Rhoads et al