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The SLs-ITZ synergy provides a valuable strategy for modifying pathogendrug interactions for developing novel approaches to antifungal therapies

acidophilus NCFM has been shown to reduce fever and respiratory symptoms, indicating that reinforcing the gut barrier supports systemic immune defenses (87)

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however, their poor stability, which results in rapid loss of their activity, together with their rapid clearance from defected tissues (when applied as free molecules) is a serious drawback for their use

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