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FH4 est un co-facteur qui transfrent des groupements methyl dans plusieurs voies mtaboliques essentielles comme : - la synthse de l'ADN : FH4 a un rle essentiel comme co-facteur dans la synthse des bases puriques et pyrimidiques, notamment dans la conversion du DUMP (deoxyuridylate monophosphate) en DTMP (deoxythymidylate monophosphate) tape catalyse par la thymidylate synthtase (cible du 5-fluorouracile) et tape limitante dans la synthse de l'ADN - le mtabolisme des acides amins : conversion de lhomocystine en mthionine par la mthionine synthtase rductase, faisant intervenir la fois les folates et la vitamine B12