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We further conducted integrative analyses combining genomic data and diet/lifestyle factors, to systematically elucidate genetic determinants, functional enrichments and potential tissue origin for T2D-associated metabolites

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Furthermore, the low consumption of vegetables and fruits causes a lack of exogenous antioxidants, while an excessive intake of animal proteins (mainly red and processed meat) and fats has been associated with increased oxidants, increasing the risk of immune-mediated disorders, including autoimmune thyroid diseases [186, 187]

Data availability Higher resolution larger images of the current study available from the corresponding author on reasonable request

P., Vacante, M., Giordano, M., Pennisi, G., Bella, R., Rampello, L