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MarkovicJMoraNJBrosetaAMGimenoAde-la-ConcepcinNViaJet alThe depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts

Such formulations may also enable targeted tissue delivery, thereby enhancing therapeutic efficacy and reducing systemic exposure

In pyrimidine biosynthesis, one glutamine molecule is consumed by a carbamoyl phosphate synthetase enzyme (CPS1 or CPS2, which are localized in the mitochondria and cytosol, respectively)

Future studies should validate our findings in genetic models to determine whether the observed gut-brain interactions are generalizable across ASD subtypes

doi: 10.1186/s10194-018-0910-y