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It also compounds the risk of functional decline and bone density loss, which is the opposite of what a longevity-focused patient is working toward

Another factor is reproducibility

However, it only increases the percentage of the EFSAs acute reference dose (ARfD) of 20 g/kg body weight from 7.4% to 8.9% (lower bound) or from 13% to 15% (upper bound), which is negligible for people with normal kidney function

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How I try to mimic that is with resistance in blood flow, which restricts oxygen to the muscle, builds up lactate, now used as an energy source which we previously thought was a negative byproduct