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Therapeutic potential of PKC inhibitors in painful diabetic neuropathy

The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study

Reduced inflammation, improved tissue organization, and blood vessel formation become potentially visible on ultrasound or MRI

Ask him what are the signs of toxicity - and I'm willing to bet you will hear a list of all the B12 deficiency symptoms that he chooses not to recognise as such, even if you mentioned them all 15 years ago to the first GP

Those taking certain medications - Some medications will impact your likelihood of developing B12 deficiency

Your care team can suggest a sensible cadence based on your plan and how you respond, and will keep your expectations grounded throughout