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These cytotoxic agents, commonly referred to as chemotherapeutic drugs, can act in several ways, such as interfering with DNA replication, disrupting cell division, or triggering apoptosis (programmed cell death) [56]

The peptide's circulating half-life is short (minutes to hours), but the transcription factor cascades it triggers persist for days

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Finasteride 1 mg daily or dutasteride 0.5 mg daily (prescription, addresses DHT upstream)

Gudkov, p16(Ink4a) and senescence-associated -galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli