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Curcumin reduces inflammatory signaling (NF-B pathway) to protect retinal and neural tissue

This pathway is a direct regulator of glycolysis via pyruvate kinase M2 (PKM2), a key sensor controlling the glycolytic flux

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In this setting, oxidative stress acts primarily as a persistent, low-grade metabolic stressor, arising from mitochondrial dysfunction and NADPH oxidase activation, and amplified by inflammatory cytokines (TNF, IL-6)