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In the context of metabolic disequilibrium, excessive lipid accumulation and mtROS activate the NLRP3 inflammasome in both hepatocytes and Kupffer cells

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showed that low serum vitamin B 12 levels were observed in individuals taking metformin at doses over 2000 mg/day, and a prevalence of mild neuropathy reaching 22.3% in the metformin-users group compared to 15.1% in the non-metformin users group, consistent with the results of previous studies in the literature [49]