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It works by activating GLP-1 receptors in your brain to promote satiety and reduce hunger and food cravings

Kosiborod MN, Deanfield J, Pratley R, Borlaug BA, Butler J, Davies MJ, et al

J Dent Anesth Pain Med

This is the primary reason the American Academy of Pediatrics recommends supplementing breastfed infants with 400 IU per day (formula is fortified with vitamin D, so the levels are consistent, which is why this recommendation is solely for breastfed infants)

A level of less than 150 pg per mL (111 pmol per L) is diagnostic for deficiency Methylmalonic Acid (MMA) test: MMA is a substance produced in the body during the breakdown of certain amino acids

The titration protocol exists because GLP-1 receptor agonists cause gastrointestinal side effects, primarily nausea, that are dose-dependent