interaction of chloroacetamide electrophiles with cellular glutathion An Activity-Guided Map Electrophile-Cysteine Interactions in Primary Human T Cells: Cell Expanding the Chemistry of Dihaloacetamides
Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines Journal of Medicinal Chemistry Transduction of Redox Signaling by Electrophile Protein Reactions Science Signaling Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS: Cell Chemical Biology Design, synthesis, and biological evaluation of nitroisoxazole containing spiro[pyrrolidin oxindole] derivatives as novel glutathione peroxidase 4 mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation ScienceDirect Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C terminal Hydrolase L3 bioRxiv Selective covalent targeting of GPX4 using masked nitrile oxide electrophiles Nature Chemical Biology
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