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AD gene expression profiles were acquired from the Gene Expression Omnibus (GEO) database, with a specific focus on data generated using the Illumina HumanHT-12 V4.0 Expression Microbead Chip platform (accession number: GSE52093)

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Future translational efforts must prioritize strategies that enhance brain specificity (e.g., targeted delivery systems, BBB-penetrating analogs) while conducting comprehensive long-term safety assessments