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Consuming gluten with celiac disease can cause irreparable damage to the gut which means all gluten-containing foods must be avoided

Urakaze M, Kobashi C, Satou Y, Shigeta K, Toshima M, Takagi M, Nishida H (2021) The beneficial effects of astaxanthin on glucose metabolism and modified low-density lipoprotein in healthy volunteers and subjects with prediabetes

10.1016/j.mri.2015.12.005 226 RajP

Niacinamide: Evens out skin tone around the eyes, reduces minor pigmentation and improves skin texture

Oral's side effects are digestive (it's processed through the gut)

Exercise-induced muscle damage can lead to inflammation and immune system activation, which can impair muscle function