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Clinical safety studies involving approximately 900 participants showed no clinically significant hormonal changes with AOD-9604, consistent with its peripheral, fat-tissue-specific mechanism of action

Its failure in clinical trials does not negate potential mechanistic value in understanding fat cell metabolism

Overall, it exhibited a safety and tolerability profile comparable to placebo

However, it is noteworthy that knockdown of NNMT does not seem to affect NAD + levels in the liver, indicating potential divergent regulatory mechanisms of NNMT in these tissues and suggesting the existence of redundant pathways in NAD + metabolism regulation (Kraus et al., 2014)

14 , e12860 (2022)

[1] In practice, 1 mL (which provides the full 100 mg of B and B, etc.) is a common dose for general supplementation in deficient states, but clinicians may start with lower volumes for mild deficiencies or in smaller patients