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the predicted binding mode of 1j indicates the C5-amino substituent forms hydrogen bonding interaction with the carboxylic backbone of the Ser201 residue and a hydrophobic bonding with the Ser213 residue unlike the NCA amide group that is in hydrogen bonding distance from with the NNMT Ser213 residue

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IMiD reduces the IKZF1/3 and increases the CD38, which is benefit for Daratumumab treatment

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It helps in the production of red blood cells, which carry oxygen throughout the body

But no human trials exist yet