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Concurrently, curcumin enhances neuroplasticity by upregulating BDNF/TrkB signaling and activating ERK/CREB pathways, thereby reversing synaptic deficits and promoting neural repair

2021 May;14(2):161-9

These cells also have an overall reduction in metabolic activity, with downregulated pentose phosphate pathway (PPP), explaining their vulnerability to oxidative stress 42