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For example, a 2022 pre-clinical study in mice showed that GlyNAC increased the mouse lifespan by 24% and reversed many hallmarks of aging, including mitochondrial dysfunction and genomic damage.* Overall, glutathione is undeniably essential at all agesbut older adults are particularly susceptible to its decline and the oxidative stress that can influence virtually everything from our heads to our toes

Recently, neural activity mediated by NMDA-receptors (NMDAR) has been coupled with transcriptional activation of glutamate-cysteine ligase, a key enzyme in GSH production, leading to a sustained GSH-based protection against an oxidative insult 26

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