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IGF-1 LR3 and the IGFBP Regulatory System Structural analysis confirmed that among the series of N-terminal IGF-1 analogues tested, Long Arg3 IGF-1 demonstrated the greatest growth-promoting potential exceeding shorter analogues such as Arg3 IGF-1, Gly3 IGF-1, and Des(1-3) IGF-1 directly correlating with its superior IGFBP evasion profile

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[DOI] [PubMed] [Google Scholar] 3.Papamichael K, Chachu KA, Vajravelu RK, et al

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Alternative Routes of Administration & the First-Pass Effect There are several reasons for different routes of administration used in clinical medicine ( Table 33 )for convenience (eg, oral), to maximize concentration at the site of action and minimize it elsewhere (eg, topical), to prolong the duration of drug absorption (eg, transdermal), or to avoid the first-pass effect (sublingual or rectal)