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In this work, the main phenotypic screening was fundus photography followed by scoring of yellow fundus spots using a special fundus spot scale (see below)

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Following hepatic secretion, it incorporates additional apoC from HDL particles within the circulation

PLoS Biol 2: e280 Mostafa YA, Taylor SD (2013) Steroid derivatives as inhibitors of steroid sulfatase

This dysregulation can be achieved by directly oxidizing critical biomolecules (DNA, proteins, lipids) and thereby disrupting essential cellular signaling pathways